Until recently, it was believed that most chronic kidney disease inevitably progresses to end stage renal disease. However, much recent research has shown that it is possible to modify this process and to slow or even halt the progression of kidney disease, even when the glomerular filtration rate has fallen significantly.
Certain blood pressure lowering drugs have a beneficial effect on the pressures and flows in the glomerular capillaries, especially drugs that lower angiotensin levels. Angiotensin converting enzyme (ACE) inhibitors such as captopril and enalapril, have been shown to lower glomerular capillary pressure and slow the progression of kidney impairment. ACE inhibitors are particularly effective in diabetics with kidney failure.
It is important for patients with kidney failure to have their kidney function monitored regularly, preferably by a nephrologist, so that treatments can be adjusted accordingly.